Early life origins of chronic obstructive pulmonary disease
Identifieur interne : 007100 ( Main/Exploration ); précédent : 007099; suivant : 007101Early life origins of chronic obstructive pulmonary disease
Auteurs : C. Svanes [Norvège, Espagne] ; J. Sunyer [Espagne] ; E. Plana [Espagne] ; S. Dharmage [Australie] ; J. Heinrich [Allemagne] ; D. Jarvis [Royaume-Uni] ; R. De Marco [Italie] ; D. Norb Ck [Suède] ; C. Raherison [France] ; S. Villani [Italie] ; M. Wjst [Allemagne] ; K. Svanes [Norvège] ; J M Ant [Espagne]Source :
- Thorax [ 0040-6376 ] ; 2010-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Tabagisme, Classe sociale.
English descriptors
- KwdEn :
- Adult asthma, Adult fev1, Adult lung function, Adult smoking, Anesthesia, Asthma, Asthma childhood asthma, Atopy, Baseline, Baseline fev1, Birth weight, Cardiology, Centre, Childhood asthma, Childhood disadvantage, Childhood disadvantage factors, Childhood factor, Childhood factors, Chronic obstructive pulmonary disease, Cigarette smoking, Circulatory system, Complete data, Copd, Current smokers, Disadvantage, Early, Early life, Early life disadvantage, Early life environment, Early life factors, Early life origins, Ecrhs, European community, Expiratory, Expiratory volume, Fev1, Health survey, Heavy smoking, High education, Individual childhood disadvantage factors, Larger decline, Lower fev1, Lower lung function, Lung, Lung function, Lung function decline, Lung function measurements, Maternal asthma, Maternal smoking, Median, Median height, More childhood disadvantage factors, Online, Online supplement, Origin, Other childhood factors, Parental smoking, Paternal asthma, Present study, Professional subjects, Pulmonary disease, Pulmonary disease table, Respir, Respir crit care, Respiratory infection, Respiratory symptoms, Smoking, Smoking status, Social class, Specific number, Thorax.
- Teeft :
- Adult asthma, Adult fev1, Adult lung function, Adult smoking, Asthma, Asthma childhood asthma, Atopy, Baseline, Baseline fev1, Birth weight, Centre, Childhood asthma, Childhood disadvantage, Childhood disadvantage factors, Childhood factor, Childhood factors, Cigarette smoking, Complete data, Copd, Current smokers, Disadvantage, Early life, Early life disadvantage, Early life environment, Early life factors, Early life origins, Ecrhs, European community, Expiratory, Expiratory volume, Fev1, Health survey, Heavy smoking, High education, Individual childhood disadvantage factors, Larger decline, Lower fev1, Lower lung function, Lung, Lung function, Lung function decline, Lung function measurements, Maternal asthma, Maternal smoking, Median, Median height, More childhood disadvantage factors, Online, Online supplement, Other childhood factors, Parental smoking, Paternal asthma, Present study, Professional subjects, Pulmonary disease, Pulmonary disease table, Respir, Respir crit care, Respiratory infection, Respiratory symptoms, Smoking, Smoking status, Social class, Specific number, Thorax.
Abstract
Background: Early life development may influence subsequent respiratory morbidity. The impact of factors determined in childhood on adult lung function, decline in lung function and chronic obstructive pulmonary disease (COPD) was investigated. Methods: European Community Respiratory Health Survey participants aged 20–45 years randomly selected from general populations in 29 centres underwent spirometry in 1991–3 (n = 13 359) and 9 years later (n = 7738). Associations of early life factors with adult forced expiratory volume in 1 s (FEV1), FEV1 decline and COPD (FEV1/FVC ratio <70% and FEV1 <80% predicted) were analysed with generalised estimating equation models and random effects linear models. Results: Maternal asthma, paternal asthma, childhood asthma, maternal smoking and childhood respiratory infections were significantly associated with lower FEV1 and defined as “childhood disadvantage factors”; 40% had one or more childhood disadvantage factors which were associated with lower FEV1 (men: adjusted difference 95 ml (95% CI 67 to 124); women: adjusted difference 60 ml (95% CI 40 to 80)). FEV1 decreased with increasing number of childhood disadvantage factors (⩾3 factors, men: 274 ml (95% CI 154 to 395), women: 208 ml (95% CI 124 to 292)). Childhood disadvantage was associated with a larger FEV1 decline (1 factor: 2.0 ml (95% CI 0.4 to 3.6) per year; 2 factors: 3.8 ml (95% CI 1.0 to 6.6); ⩾3 factors: 2.2 ml (95% CI −4.8 to 9.2)). COPD increased with increasing childhood disadvantage (1 factor, men: OR 1.7 (95% CI 1.1 to 2.6), women: OR 1.6 (95% CI 1.01 to 2.6); ⩾3 factors, men: OR 6.3 (95% CI 2.4 to 17), women: OR 7.2 (95% CI 2.8 to 19)). These findings were consistent between centres and when subjects with asthma were excluded. Conclusions: People with early life disadvantage have permanently lower lung function, no catch-up with age but a slightly larger decline in lung function and a substantially increased COPD risk. The impact of childhood disadvantage was as large as that of heavy smoking. Increased focus on the early life environment may contribute to the prevention of COPD.
Url:
DOI: 10.1136/thx.2008.112136
Affiliations:
- Allemagne, Australie, Espagne, France, Italie, Norvège, Royaume-Uni, Suède
- Angleterre, Catalogne, East Middle Sweden, Grand Londres, Svealand, Victoria (État), Île-de-France
- Barcelone, Londres, Melbourne, Paris, Uppsala
- Université Pompeu Fabra, Université d'Uppsala, Université de Melbourne
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult asthma</term>
<term>Adult fev1</term>
<term>Adult lung function</term>
<term>Adult smoking</term>
<term>Anesthesia</term>
<term>Asthma</term>
<term>Asthma childhood asthma</term>
<term>Atopy</term>
<term>Baseline</term>
<term>Baseline fev1</term>
<term>Birth weight</term>
<term>Cardiology</term>
<term>Centre</term>
<term>Childhood asthma</term>
<term>Childhood disadvantage</term>
<term>Childhood disadvantage factors</term>
<term>Childhood factor</term>
<term>Childhood factors</term>
<term>Chronic obstructive pulmonary disease</term>
<term>Cigarette smoking</term>
<term>Circulatory system</term>
<term>Complete data</term>
<term>Copd</term>
<term>Current smokers</term>
<term>Disadvantage</term>
<term>Early</term>
<term>Early life</term>
<term>Early life disadvantage</term>
<term>Early life environment</term>
<term>Early life factors</term>
<term>Early life origins</term>
<term>Ecrhs</term>
<term>European community</term>
<term>Expiratory</term>
<term>Expiratory volume</term>
<term>Fev1</term>
<term>Health survey</term>
<term>Heavy smoking</term>
<term>High education</term>
<term>Individual childhood disadvantage factors</term>
<term>Larger decline</term>
<term>Lower fev1</term>
<term>Lower lung function</term>
<term>Lung</term>
<term>Lung function</term>
<term>Lung function decline</term>
<term>Lung function measurements</term>
<term>Maternal asthma</term>
<term>Maternal smoking</term>
<term>Median</term>
<term>Median height</term>
<term>More childhood disadvantage factors</term>
<term>Online</term>
<term>Online supplement</term>
<term>Origin</term>
<term>Other childhood factors</term>
<term>Parental smoking</term>
<term>Paternal asthma</term>
<term>Present study</term>
<term>Professional subjects</term>
<term>Pulmonary disease</term>
<term>Pulmonary disease table</term>
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<term>Respiratory infection</term>
<term>Respiratory symptoms</term>
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<term>Social class</term>
<term>Specific number</term>
<term>Thorax</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Anesthésie</term>
<term>Appareil circulatoire</term>
<term>Bronchopneumopathie chronique obstructive</term>
<term>Cardiologie</term>
<term>Origine</term>
<term>Précoce</term>
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<term>Adult lung function</term>
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<term>Atopy</term>
<term>Baseline</term>
<term>Baseline fev1</term>
<term>Birth weight</term>
<term>Centre</term>
<term>Childhood asthma</term>
<term>Childhood disadvantage</term>
<term>Childhood disadvantage factors</term>
<term>Childhood factor</term>
<term>Childhood factors</term>
<term>Cigarette smoking</term>
<term>Complete data</term>
<term>Copd</term>
<term>Current smokers</term>
<term>Disadvantage</term>
<term>Early life</term>
<term>Early life disadvantage</term>
<term>Early life environment</term>
<term>Early life factors</term>
<term>Early life origins</term>
<term>Ecrhs</term>
<term>European community</term>
<term>Expiratory</term>
<term>Expiratory volume</term>
<term>Fev1</term>
<term>Health survey</term>
<term>Heavy smoking</term>
<term>High education</term>
<term>Individual childhood disadvantage factors</term>
<term>Larger decline</term>
<term>Lower fev1</term>
<term>Lower lung function</term>
<term>Lung</term>
<term>Lung function</term>
<term>Lung function decline</term>
<term>Lung function measurements</term>
<term>Maternal asthma</term>
<term>Maternal smoking</term>
<term>Median</term>
<term>Median height</term>
<term>More childhood disadvantage factors</term>
<term>Online</term>
<term>Online supplement</term>
<term>Other childhood factors</term>
<term>Parental smoking</term>
<term>Paternal asthma</term>
<term>Present study</term>
<term>Professional subjects</term>
<term>Pulmonary disease</term>
<term>Pulmonary disease table</term>
<term>Respir</term>
<term>Respir crit care</term>
<term>Respiratory infection</term>
<term>Respiratory symptoms</term>
<term>Smoking</term>
<term>Smoking status</term>
<term>Social class</term>
<term>Specific number</term>
<term>Thorax</term>
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<front><div type="abstract">Background: Early life development may influence subsequent respiratory morbidity. The impact of factors determined in childhood on adult lung function, decline in lung function and chronic obstructive pulmonary disease (COPD) was investigated. Methods: European Community Respiratory Health Survey participants aged 20–45 years randomly selected from general populations in 29 centres underwent spirometry in 1991–3 (n = 13 359) and 9 years later (n = 7738). Associations of early life factors with adult forced expiratory volume in 1 s (FEV1), FEV1 decline and COPD (FEV1/FVC ratio <70% and FEV1 <80% predicted) were analysed with generalised estimating equation models and random effects linear models. Results: Maternal asthma, paternal asthma, childhood asthma, maternal smoking and childhood respiratory infections were significantly associated with lower FEV1 and defined as “childhood disadvantage factors”; 40% had one or more childhood disadvantage factors which were associated with lower FEV1 (men: adjusted difference 95 ml (95% CI 67 to 124); women: adjusted difference 60 ml (95% CI 40 to 80)). FEV1 decreased with increasing number of childhood disadvantage factors (⩾3 factors, men: 274 ml (95% CI 154 to 395), women: 208 ml (95% CI 124 to 292)). Childhood disadvantage was associated with a larger FEV1 decline (1 factor: 2.0 ml (95% CI 0.4 to 3.6) per year; 2 factors: 3.8 ml (95% CI 1.0 to 6.6); ⩾3 factors: 2.2 ml (95% CI −4.8 to 9.2)). COPD increased with increasing childhood disadvantage (1 factor, men: OR 1.7 (95% CI 1.1 to 2.6), women: OR 1.6 (95% CI 1.01 to 2.6); ⩾3 factors, men: OR 6.3 (95% CI 2.4 to 17), women: OR 7.2 (95% CI 2.8 to 19)). These findings were consistent between centres and when subjects with asthma were excluded. Conclusions: People with early life disadvantage have permanently lower lung function, no catch-up with age but a slightly larger decline in lung function and a substantially increased COPD risk. The impact of childhood disadvantage was as large as that of heavy smoking. Increased focus on the early life environment may contribute to the prevention of COPD.</div>
</front>
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<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Norvège</li>
<li>Royaume-Uni</li>
<li>Suède</li>
</country>
<region><li>Angleterre</li>
<li>Catalogne</li>
<li>East Middle Sweden</li>
<li>Grand Londres</li>
<li>Svealand</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Londres</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Uppsala</li>
</settlement>
<orgName><li>Université Pompeu Fabra</li>
<li>Université d'Uppsala</li>
<li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Norvège"><noRegion><name sortKey="Svanes, C" sort="Svanes, C" uniqKey="Svanes C" first="C" last="Svanes">C. Svanes</name>
</noRegion>
<name sortKey="Svanes, K" sort="Svanes, K" uniqKey="Svanes K" first="K" last="Svanes">K. Svanes</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Svanes, C" sort="Svanes, C" uniqKey="Svanes C" first="C" last="Svanes">C. Svanes</name>
</region>
<name sortKey="Ant, J M" sort="Ant, J M" uniqKey="Ant J" first="J M" last="Ant">J M Ant</name>
<name sortKey="Ant, J M" sort="Ant, J M" uniqKey="Ant J" first="J M" last="Ant">J M Ant</name>
<name sortKey="Plana, E" sort="Plana, E" uniqKey="Plana E" first="E" last="Plana">E. Plana</name>
<name sortKey="Sunyer, J" sort="Sunyer, J" uniqKey="Sunyer J" first="J" last="Sunyer">J. Sunyer</name>
<name sortKey="Sunyer, J" sort="Sunyer, J" uniqKey="Sunyer J" first="J" last="Sunyer">J. Sunyer</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Dharmage, S" sort="Dharmage, S" uniqKey="Dharmage S" first="S" last="Dharmage">S. Dharmage</name>
</region>
</country>
<country name="Allemagne"><noRegion><name sortKey="Heinrich, J" sort="Heinrich, J" uniqKey="Heinrich J" first="J" last="Heinrich">J. Heinrich</name>
</noRegion>
<name sortKey="Wjst, M" sort="Wjst, M" uniqKey="Wjst M" first="M" last="Wjst">M. Wjst</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jarvis, D" sort="Jarvis, D" uniqKey="Jarvis D" first="D" last="Jarvis">D. Jarvis</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="De Marco, R" sort="De Marco, R" uniqKey="De Marco R" first="R" last="De Marco">R. De Marco</name>
</noRegion>
<name sortKey="Villani, S" sort="Villani, S" uniqKey="Villani S" first="S" last="Villani">S. Villani</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Norb Ck, D" sort="Norb Ck, D" uniqKey="Norb Ck D" first="D" last="Norb Ck">D. Norb Ck</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Raherison, C" sort="Raherison, C" uniqKey="Raherison C" first="C" last="Raherison">C. Raherison</name>
</region>
</country>
</tree>
</affiliations>
</record>
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